PUBLICATIONS

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  1. "Bantam regulates the adult sleep circuit in Drosophila" Hobin, M, Dorfman, K, Adel, M, Rivera-Rodriguez, EJ and Griffith, LC (2021) Biorxiv https://www.biorxiv.org/content/10.1101/2021.08.21.457226v1

  2. "The role of dopamine in associative learning in Drosophila: An updated unified model” Adel, M and Griffith, LC (2021) Neurosci Bull  37:831-852

  3. “Rest is required to learn an appetitively-reinforced operant task in Drosophila” (2021) Front. Behav. Neurosci. doi.org/10.3389/fnbeh.2021.681593

  4. “Availability of food determines the need for sleep in memory consolidation.” Chouhan, N.S., Griffith, L.C., Haynes, P. and Sehgal, A. (2020) Nature 589:582-585

  5. "Regulation of olfactory associative memory by the circadian clock output signal Pigment-dispersing factor (PDF)" Flyer-Adams, J.G., Rivera-Rodriguez, E.J., Mardovin, J.D., Yu, J., Griffith, L.C. (2020) J Neurosci 40:9066-9077.
     

  6. "Covert sleep-related biological processes are revealed by probabilistic analysis in Drosophila." Wiggin TD, Goodwin PR, Donelson NC, Liu C, Trinh K, Sanyal S, Griffith LC. (2020) PNAS (18) 10024-10034
     

  7. "The Conserved microRNA miR-34 Regulates Synaptogenesis via Coordination of Distinct Mechanisms in Presynaptic and Postsynaptic Cells" McNeill EM, Warinner C, Alkins S, Taylor A,  Heggeness H, DeLucaTF,  Fulga TA, Wall DP, Griffith LC, Van Vactor D (2020) Nature Communications 2020 Feb 27;11(1):1092. doi: 10.1038/s41467-020-14761-8.
     

  8. "MicroRNAs Regulate Multiple Aspects of Locomotor Behavior in Drosophila" Donelson NC, Dixit R, Pichardo-Casas I, Chiu EY, Ohman RT, Slawson JB, Klein M, Fulga TA, Van Vactor D and Griffith LC (2020) G3 2020 Jan 7;10(1):43-55. doi: 10.1534/g3.119.400793.
     

  9. "A Serotonin-Modulated Circuit Controls Sleep Architecture to Regulate Cognitive Function Independent of Total Sleep in Drosophila" Liu, C., Meng, Z., Wiggin, T.D., Yu, J., Reed, M.L., Guo, F., Zhang, Y., Rosbash, M and Griffith, L.C. (2019) Current Biology 2019 Nov 4;29(21):3635-3646.e5. doi: 10.1016/j.cub.2019.08.079.
     

  10. "Memories of John Lisman." Otmakhova, N.A., Otmakhov, N. and Griffith, L.C. (2018) Frontiers in Neural Circuits. 2018 Dec 28;11(1):76. doi: 10.3389/fncir.2018.00024.
     

  11. "MicroRNAs Regulate Sleep and Sleep Homeostasis in Drosophila." Goodwin PR, Meng A, Moore J, Hobin M, Fulga TA, Van Vactor D, Griffith LC. (2018) Cell Rep. 2018 Jun 26;23(13):3776-3786. doi: 10.1016/j.celrep.2018.05.078.
     

  12. "Regulation of Eag by Ca2+/calmodulin controls presynaptic excitability in Drosophila." Bronk P, Kuklin EA, Gorur-Shandilya S, Liu C, Wiggin TD, Reed ML, Marder E, Griffith LC. (2018) J Neurophysiol. 2018 May 1;119(5):1665-1680. doi: 10.1152/jn.00820.2017.
     

  13. "The Long 3'UTR mRNA of CaMKII Is Essential for Translation-Dependent Plasticity of Spontaneous Release in Drosophila melanogaster." Kuklin EA, Alkins S, Bakthavachalu B, Genco MC, Sudhakaran I, Raghavan KV, Ramaswami M, Griffith LC. (2017) J Neurosci. 2017 Nov 1;37(44):10554-10566. doi: 10.1523/JNEUROSCI.1313-17.2017.
     

  14. Editorial overview: Neurobiology of learning and plasticity 2017. Vogels TP, Griffith LC. (2017) Curr Opin Neurobiol. 2017 Apr;43:A1-A5. doi: 10.1016/j.conb.2017.04.002. Epub 2017 Apr 17.
     

  15. "Nonreciprocal homeostatic compensation in Drosophila potassium channel mutants." Kim EZ, Vienne J, Rosbash M, Griffith LC. (2017) J Neurophysiol. 2017 Jun 1;117(6):2125-2136. doi: 10.1152/jn.00002.2017. Epub 2017 Mar 15.
     

  16. "Reorganization of Sleep by Temperature in Drosophila Requires Light, the Homeostat, and the Circadian Clock." Parisky KM, Agosto Rivera JL, Donelson NC, Kotecha S, Griffith LC. (2016) Curr Biol. 2016 Apr 4;26(7):882-92. doi: 10.1016/j.cub.2016.02.011.
     

  17. "Sleep in Populations of Drosophila Melanogaster." Liu C, Haynes PR, Donelson NC, Aharon S, Griffith LC. (2015) eNeuro. 2015 Aug 21;2(4). pii: ENEURO.0071-15.2015. doi: 10.1523/ENEURO.0071-15.2015. eCollection 2015 Jul-Aug.
     

  18. "Model Organisms in G Protein-Coupled Receptor Research." Langenhan T, Barr MM, Bruchas MR, Ewer J, Griffith LC, Maiellaro I, Taghert PH, White BH, Monk KR. (2015) Mol Pharmacol. 2015 Sep;88(3):596-603. doi: 10.1124/mol.115.098764.
     

  19. “A single pair of neurons links sleep to memory consolidation in Drosophila melanogaster”. Haynes, PR, Christmann, BL, and Griffith, LC (2015) eLife, doi: 10.7554/eLife.03868 PMC4305081
     

  20. “Regulation of dopamine release by CASK-ß modulates locomotor initiation in Drosophila melanogaster”. Slawson, J.B., Kuklin, EA, Mukherjee, K, Pirez, N., Donelson, N.C., and Griffith, L.C. (2014) Front Behav Neurosci, doi: 10.3389/fnbeh.2014.00394 PMC4235261
     

  21. “Neuron-specific protein interactions of Drosophila CASK-ß are revealed by mass spectrometry”. Mukherjee, K., Slawson, J.B., Christmann, B.L. and Griffith, L.C. (2014) Front Molec Neurosci, doi: 10.3389/fnmol.2014.00058 PMC4075472
     

  22. “The Drosophila neuropeptides PDF and sNPF have opposing electrophysiological and molecular effects on target cells". Vecsey, C.G., Pirez, N. and Griffith, L.C. (2014) J. Neurophys. 110:1033-1045 PMC3949227

  23. “Up all night on a redeye flight”. Griffith, L.C. (2014) eLife, doi: 10.7554/eLife.02087 PMC3912630.
     

  24. “A gustatory receptor paralog controls rapid warmth avoidance in Drosophila”. Ni, L., Bronk, P. Chang, E.C., Lowell, A.M., Flam, J.O., Panzano, V.C., Theobald, D.L., Griffith, L.C. and Garrity, P.A. (2013)Nature, 500:580-584 PMC3758369.
     

  25. “Daily rhythms in locomotor circuits in Drosophila involve PDF”. Pirez, N., Christmann, B.L. and Griffith, L.C. (2013) J. Neurophysiol. 100:700-708 PMC3742988
     

  26. “Neuromodulatory control of sleep in Drosophila melanogaster: Integration of competing and complementary behaviors”. Griffith, L.C. (2013) Curr. Op. Neurobiol. 5:819-823 PMC3783581.
     

  27. “Short neuropeptide F is a sleep-promoting inhibitory modulator”. Shang, Y., Donelson, N.C., Vecsey, C.G., Guo, F., Rosbash, M. and Griffith, L.C. (2013) Neuron, 80:171-183 PMC3792499.
     

  28. “DlgS97/SAP97, a neuronal isoform of Discs Large, regulates ethanol tolerance”. Maiya, R., Lee, S. Berger, K.H., Kong, E.C., Slawson, J.B., Griffith, L.C., Huganir, R.L., Margolis, B. and Heberlein, U. (2012) PLoSONE, 7(11):e48967 PMC3492131.
     

  29. “Autonomous circuitry for substrate exploration in freely moving Drosophila larvae”. Berni, J., Pulver, S.R., Griffith, L.C. and Bate, M. (2012) Curr. Biol. 22:1861-1870.
     

  30. “Song choice is modulated by female movement in Drosophila males”. Trott, A., Donelson, N.C., Griffith, L.C. and Ejima, A. (2012) PLoS ONE 7(9):e46025 PMC3458092.
     

  31. “High-resolution positional tracking for long-term analysis of Drosophila sleep and locomotion using the “Tracker” program”. Donelson, N., Kim, E.Z., Slawson, J.B., Vecsey, C.G., Huber, R. and Griffith, L.C. (2012) PLoS ONE 7(5):e37250 PMC3352887.
     

  32. “Identifying behavioral circuits in Drosophila melanogaster: Moving targets in a flying insect”. Griffith, L.C. (2012) Curr. Op. Neurobiol. 22:609-614 PMC3340460.
     

  33. “Imaging analysis of clock neurons reveals light buffers the wake-promoting effect of dopamine”. Shang, Y., Haynes, P., Pirez, N., Harrington, K.I., Pollack, J., Hong, P. Griffith, L.C., and Rosbash, M. (2011) Nat. Neurosci. 14:889-895 PMC3424274
     

  34. "Circadian biology: the supporting cast takes on a starring role". Griffith LC. (2011) Curr Biol. 2011 May 10;21(9):R313-4.
     

  35. "Imaging analysis of clock neurons reveals light buffers the wake-promoting effect of dopamine." Shang Y, Haynes P, Pírez N, Harrington KI, Guo F, Pollack J, Hong P, Griffith LC, Rosbash M. (2011)Nat Neurosci. 2011 Jun 19;14(7):889-95.
     

  36. "Central regulation of locomotor behavior of Drosophila melanogaster depends on a CASK isoform containing CaMK-like and L27 domains." Slawson JB, Kuklin EA, Ejima A, Mukherjee K, Ostrovsky L, Griffith LC. (2011) Genetics. 2011 Jan;187(1):171-84.
     

  37. “Analysis of Drosophila TRPA1 reveals an ancient origin for human chemical nociception”. Kang, K., Pulver, S.R., Panzano, V.C., Chang, E.C., Griffith, L.C., Theobold, D.L. and Garrity, P.A. (2010) Nature 464:597-600.
     

  38. “Spike integration and cellular memory in a rhythmic network from the dynamics of a Na+/K+ pump current”. Pulver, S.R. and Griffith, L.C. (2010) Nat. Neurosci. 13:53-59 PMC19966842.
     

  39. “Attention K-Mart shoppers: Blowout on aisle 7!". Griffith, L.C. (2009) Neuron 64:443-445 PMC2742166.
     

  40. “CaMKII uses GTP as a phosphate donor for both substrate and autophosphorylation”. Bostrom, S.L., Dore, J. and Griffith L.C. (2009) Biochem. Biophys. Res. Comm. 390:1154-1159 PMC2787665.
     

  41. “Courtship learning in Drosophila melanogaster: Diverse plasticity of a reproductive behavior". Griffith, L.C. and Ejima, A. (2009) Learn. & Mem. 16:743-750.
     

  42. “Temporal dynamics of neuronal activation by channelrhodopsin-2 and TRPA1 determine behavioral output in Drosophila larvae”. Pulver, S.R., Pashkovski, S.L., Hornstein, N.J., Garrity, P.A., Griffith, L.C. (2009). J. Neurophys. 101:3075-3088 PMC2694103.
     

  43. “High-resolution video tracking of locomotion in adult Drosophila melanogaster”. Slawson, J.B., Kim, E.Z. and Griffith, L.C. (2009) J. Vis. Exp. pii: 1096. doi: 10.3791/1096 PMC2762895.
     

  44. “Channelrhodopsin2-mediated stimulation of synaptic potentials at Drosophila neuromuscular junctions”. Hornstein, N.J., Pulver, S.R. and Griffith, L.C. (2009) J. Vis. Exp. 6 (25). pii:1133. doi: 10.3791/1133 PMCID19289998.
     

  45. “Alternative splicing of the eag potassium channel gene in Drosophila generates a novel signal transduction scaffolding protein”. Sun, X.X., Bostrom, S.L. and Griffith, L.C. (2009) Mol. Cell. Neurosci.40:338-343 PMC2646804.
     

  46. “Multimodal sensory integration of courtship stimulating cues in Drosophila melanogaster: Contextual effects on chemosensory cues”. Griffith L.C. and Ejima, A. (2009) Ann. N.Y. Acad. Sci. 1170:394-398 PMCID in process.
     

  47. “Light-arousal and circadian photoreception circuits intersect at the large PDF cells of the Drosophila brain”. Shang, Y., Griffith, L.C. and Rosbash, M. (2008) Proc. Natl. Acad. Sci. 150:19587-19594 PMC2596742.
     

  48. “PDF cells are a GABA-responsive wake-promoting component of the Drosophila sleep circuit”. Parisky, K.M., Agosto, J., Pulver, S.R., Shang, Y., Kuklin, E., Hodge, J.J.L., Kang, K., Liu, X., Garrity, P., Rosbash, M. and Griffith, L.C. (2008) Neuron 60:672-682 PMC2734413.
     

  49. “Courtship initiation is stimulated by acoustic signals in Drosophila melanogaster”. Ejima, A. and Griffith, L.C. (2008) PLoS ONE 3(9):e3246 PMC2531232.
     

  50. “CaMKII: New tricks for an old dog”. Griffith, L.C. (2008) Cell 133:5-7 PMC2655315.
     

  51. “Sleep: Hitting the reset button”. Griffith, L.C. and Rosbash, M. (2008) Nat. Neurosci. 11:123-124 PMC2655316.
     

  52. “Modulation of GABAA receptor (RDL) desensitization uncouples sleep onset and maintenance in Drosophila”. Agosto, J., Choi, J.C., Parisky, K.M., Stilwell, G., Rosbash, M. and Griffith L.C. (2008) Nat. Neurosci.11:354-359 PMC2655319.
     

  53. “Love Hangover”. Griffith, L.C. (2008) Nature 451:24-25
     

  54. “Measurement of courtship behavior in Drosophila”. Ejima, A and Griffith, L.C. (2007) CSH Protocols; doi:10.1101/pdb.prot4847.
     

  55. “Dr. Strangslug, or how I learned to stop worrying and love the brain”. Pulver, S.R. and Griffith, L.C. (2007) Nat. Neurosci. 10:933
     

  56. “A structural mechanism for maintaining the “on-state” of the CaMKII memory switch in the postsynaptic density”. Mullasseril, P., Dosemeci, A., Lisman, J.E. and Griffith, L.C. (2007) J. Neurochem. 103:357-364
     

  57. “The Drosophila ARC homolog regulates behavioral responses to starvation”. Mattaliano, M.D., Montana, E.S., Parisky, K.M., Littleton, J.T. and Griffith, L.C. (2007) Mol. Cell. Neurosci. 36:211-221.
     

  58. “Generalization of courtship learning in Drosophila is mediated by cis-vaccenyl acetate”. Ejima, A., Smith, B.P.C., Lucas, C., Van der Goes van Naters, W., Carlson, J.R., Levine, J.D. and Griffith, L.C. (2007) Curr. Biol. 17:599-605.
     

  59. “Plasticity and second messengers during synaptic development”. Griffith, L.C. and Budnik, V. (2006), In: The Fly Neuromuscular Junction: Structure and Function, International Review of Neurobiology, V 75 (Budnik, Ruiz-Canada, eds), San Diego, Elsevier Academic Press.
     

  60. “Cholinergic neurons mediate CaMKII-dependent enhancement of courtship suppression”. Mehren, J.E. and Griffith, L.C. (2006) Learn. and Mem. 13:686-689.
     

  61. “Activity-dependent gating of CaMKII autonomous activity by Drosophila CASK”. Hodge, J.J.L., Mullasseril, P. and Griffith, L.C. (2006) Neuron 51:327-337.
     

  62. "Electrophysiological and anatomical characterization of PDF-positive clock neurons in the intact adult Drosophila brain". Park, D. and Griffith, L.C. (2006) J. Neurophysiol.95:3955-60.
     

  63. "Watching the fly brain learn" . Griffith, L.C. (2006) Neuron 49:171-174.
     

  64. "Role for calcium/calmodulin-dependent protein kinase II in the p75-mediated regulation of sympathetic cholinergic transmission". Slonimsky, J.D., Mattaliano, M.D., Moon, J.-i., Griffith, L.C. and Birren, S.B. (2006) Proc. Natl. Acad. Sci. 103:2915-2919.
     

  65. "Sequential learning of pheromonal cues modulates memory consolidation in trainer-specific associative courtship conditioning." Ejima, A., Smith, B.P.C., Lucas, C., Levine, J.D. and Griffith, L.C. (2005) Curr Biol 15:194-206.
     

  66. "Shaw potassium channel genes in Drosophila " Hodge, J.J.L., Choi, J. C., O'Kane, C.J. and Griffith, L.C. (2005) J. Neurobiol. 63:235-254
     

  67. "Receptor clustering: Nothing succeeds like success." Griffith, L.C. (2004) Curr. Biol. 14:R413-R415.
     

  68. "Calcium-independent CaMKII in the adult Drosophila CNS enhances the training of pheromonal cues." Mehren, J.E. and Griffith, L.C. (2004) J. Neurosci. 24:10584-10593.
     

  69. "Unconventional sex: Fresh approaches to courtship learning." Mehren, J.E., Ejima, A. and Griffith, L.C. (2004) Curr. Opin. Neurobiol.14:745-750
     

  70. "Regulation of calcium/calmodulin-dependent protein kinase II activation by intramolecular and intermolecular interactions." Griffith, L.C. (2004) J. Neurosci. 24:8394-8398.
     

  71. "Calcium/calmodulin-dependent protein kinase II: An unforgettable kinase." Griffith, L.C. (2004) J. Neurosci. 24:8391-8393.
     

  72. "The eag potassium channel binds and locally activates CaMKII". Sun, X.X., Hodge, J.J.L., Zhou, Y., Nguyen, M. and Griffith, L.C. (2004) J Biol Chem. 279:10206-14
     

  73. "Electrophysiological and morphological characterization of identified motor neurons in the Drosophila third instar larva central nervous system." Choi, J., Park, D. and Griffith, L.C. (2004) J. Neurophysiol. 91:2353-65.
     

  74. "Regulation of the Ca2+/CaM responsive pool of CaMKII by scaffold-dependent autophosphorylation". Lu, C., Hodge, J.J.L., Sun, X.-X., Mehren, J.E. and Griffith, L.C. (2003) Neuron 40:1185-1197.
     

  75. "CaMKII, an Enzyme on the Move: Regulation of Temporospatial Localization". Griffith, L.C., Lu, C.S. and Sun, X.X. (2003) Mol. Interv. 3:386-403
     

  76. "Activity-dependent remodeling of presynaptic inputs by postsynaptic expression of activated CaMKII". Pratt, K., Watt, A., Griffith, L.C., Nelson, S.B. and Turrigiano, G.G. (2003) Neuron 39:269-281.
     

  77. "Calcium/calmodulin-dependent protein kinase II phosphorylates and regulates the Drosophila Eag potassium channel". Wang, Z., Wilson, G.F. and Griffith, L.C. (2002) J. Biol. Chem. 227:24022-24029.
     

  78. "Regulation of neuronal excitability in Drosophila by constitutively active CaMKII". Park, D., Coleman, M.J., Hodge, J.J.L., Budnik, V. and Griffith, L.C. (2002) J. Neurobiol. 52:24-42.
     

  79. "Potassium channels: the importance of transport signals." Griffith LC. (2001) Curr Biol. 11:R226-8. [abstract]
     

  80. "Alternative splicing of Drosophila calcium/calmodulin-dependent protein kinase II regulates substrate specificity and activation." GuptaRoy B, Marwaha N, Pla M, Wang Z, Nelson HB, Beckingham K, Griffith LC. (2000) Brain Res Mol Brain Res. 80:26-34.
     

  81. "Identification and characterization of a SUMO-1 conjugation system that modifies neuronal Calcium/Calmodulin-dependent protein kinase II in drosophila melanogaster." Long X, Griffith LC. (2000) J Biol Chem. 275:40765-76.
     

  82. "Visual input regulates circuit configuration in courtship conditioning of Drosophila melanogaster." Joiner MA, Griffith LC. (2000). Learn Mem. 7:32-42                 

  83. Koh, Y.H., Popova, E., Thomas, U., Griffith, L.C. and Budnik, V. (1999) "Regulation of DLG localization at synapses by CaMKII-dependent phosphorylation" Cell   98:353-363
     

  84. Joiner, M.A. and Griffith, L.C. (1999) "Mapping of the anatomical circuit of CaM kinase-dependent courtship conditioning in Drosophila"  Learn. & Mem  6:177-192
     

  85. Zhou, Y., Schopperle, W.M., Murrey, H., Jarmillo, A., Dagan, D., Griffith, L.C., Levitan, I. (1999) "A 14-3-3, Slob and Slowpoke potassium channel complex in Drosophila  presynaptic nerve terminals" Neuron   22:809-818
     

  86. Jin, P., Griffith, L.C. and Murphey, R.K. (1998) "Presynaptic Ca2+/calmodulin-dependent protein kinase II regulates habituation of a simple reflex in adult Drosophila"  J. Neurosci.  18:8955-8964
     

  87. Withers, M.D., Kennedy, M.B., Marder, E. and Griffith, L.C. (1998) "Characterization of calcium/calmodulin-dependent protein kinase II activity in the nervous system of the lobster, Panulirus interruptus"   Inv. Neurosci.  3:335-345
     

  88. Schopperle, W.M., Holmqvist, M., Zhou, Y., Wang, J., Wang, Z., Griffith, L.C., Kusinitz, R., Dagan, D. and Levitan, I. B. (1998) “Slob, a novel protein that binds to and modulates the Slowpoke calcium-dependent potassium channel” Neuron  20: 565-573
     

  89. Wilson, G.F., Wang, Z., Chouinard, S.W., Griffith, L.C. and Ganetzky, B. (1998) “Interaction of the K channel b subunit, Hyperkinetic, with EAG  family members” J. Biol. Chem.  273: 6389-6394
     

  90. Wang, Z., Palmer, G. and Griffith, L.C. (1998) “Regulation of Drosophila  Ca2+/calmodulin-dependent protein kinase II by autophosphorylation analyzed by site-directed mutagenesis”,  J. Neurochem.  71:378-387
     

  91. Griffith, L.C. (1997) “Drosophila melanogaster  as a model system for the study of the function of calcium/calmodulin-dependent protein kinase II in synaptic plasticity”, Invert. Neurosci.  3:93-102
     

  92. Joiner, M.A. and Griffith L.C. (1997) “CaM kinase II and visual input modulate memory formation in the neuronal circuit controlling courtship conditioning” J. Neurosci.  17: 9384-9391
     

  93. Barria, A., Muller, D., Derkach, V., Griffith, L.C. and Soderling, T.R. (1997) "Regulatory phosphorylation of AMPA-type glutamate receptors by CaM-KII during long-term potentiation" Science  276:2042-2045
     

  94. Otmakhov, N., Griffith, L.C. and Lisman, J.E. (1997) “Postsynaptic inhibitors of CaM-kinase block induction but not maintenance of pairing-induced LTP” J. Neurosci., 17:5357-5365
     

  95. GuptaRoy, B., Beckingham, K. and Griffith, L.C. (1996) “Functional diversity of alternatively spliced isoforms of Drosophila Ca2+/calmodulin-dependent protein kinase II: A role for the variable domain in activation” J. Biol. Chem.  271:19846-19851
     

  96. GuptaRoy, B. and Griffith, L.C. (1996) “Functional characterization of alternatively spliced isoforms of Drosophila Ca2+/calmodulin-dependent protein kinase II” J. Neurochem.  66:1282-1288
     

  97.  Wang, J., Renger, J., Griffith, L.C., Greenspan, R.J. and Wu, C.-F. (1994) “Concomitant alterations of physiological and developmental plasticity at CaM kinase II-inhibited synapses in Drosophila” Neuron  13:1373-1384